Nanoparticle Development Services for Drug Delivery Systems

Nanoparticle drug delivery systems (DDS) have emerged as a breakthrough approach to enhance the efficacy and safety of therapeutic drugs. These systems involve the encapsulation or surface attachment of drugs to nanoparticles typically 1 - 100 nm in size. By utilizing the unique properties of nanoparticles, such as their high surface area and tunable surface properties, drug delivery can be precisely controlled to improve therapeutic efficacy.

Protheragen-ING specializes in the design and development of advanced nanoparticle-based DDSs. our expertise in nanoparticle engineering and extensive knowledge in pharmaceutical sciences allows us to provide comprehensive customization services to meet the unique needs of our customers in the healthcare and pharmaceutical industries.

Fig. 1 Physicochemical properties of nanoparticles. (Yusuf A, et al. 2023)

Advantages of Nanoparticle-based DDS

• Enhanced stability and prevention of drug degradation.
• Controlled and slow release of drugs.
• Improved solubility and bioavailability of insoluble drugs.
• Targeted delivery to specific cells, tissues, or organs.
• Reduced toxicity and side effects.
• Improve therapeutic efficacy.

Our Nanoparticle DDS Development Services

We currently offer the following nanoparticle development services. These nanoparticle carriers can be surface-modified with specific ligands for effective drug delivery to achieve your goals. Customers can choose from these to realize their drug delivery studies.

• Lipid-Based Nanoparticles
• Polymer Nanoparticles
• Inorganic Nanoparticles
• Single Domain Antibody
• Protein-based Nanoparticles
• Nanocrystal
• Bio-inspired Nanoparticles

Fig. 2 Mechanisms for controlled release of drugs using different types of nanocarriers. (Patra JK, et al. 2018)

Comprehensive Nanoparticle DDS Solutions

We offer comprehensive solutions for the development of nanoparticle-based drug delivery systems, including but not limited to:

• Formulation design and optimization for specific drug molecules and therapeutic targets.
• Encapsulation and loading of various types of drugs
• Characterization of nanoparticle formulations including size, stability, drug loading, and release kinetics.
• In vitro and in vivo evaluation of nanoparticle performance and efficacy.
• Scale-up and manufacturing support for clinical translation.
• Regulatory guidance and assistance during development.

Our Nanoparticle DDS-related Technologies

We utilize state-of-the-art technology and cutting-edge techniques in our nanoparticle development services. Our advanced nanoparticle engineering capabilities include:

• Nanoemulsion and microemulsion technologies for lipid nanoparticles.
• Synthesis of polymer nanoparticles using various methods, such as emulsion polymerization or nanoprecipitation.
• Surface modification strategies for targeted drug delivery.
• Encapsulation techniques, including solvent evaporation, coalescence, or electrostatic assembly.
• Controlled release methods, such as stimuli-responsive or sustained release systems.
• Advanced characterization techniques, including dynamic light scattering, electron microscopy, and spectroscopic analysis.
• Computational modeling and simulation.

Applications of Nanoparticle DDS in Disease Treatment

Nanoparticle drug delivery systems have revolutionized the field of medicine and hold great promise in various disease treatments. Some of the applications include:

• Cancer therapy: Targeted delivery of anticancer drugs to tumor cells, reducing side effects and improving efficacy.
• Infectious diseases: Delivery of antimicrobial agents to pathogens, enhancing treatment effectiveness.
• Neurological disorders: Transport of therapeutic agents across the blood-brain barrier for the treatment of conditions like Alzheimer's and Parkinson's disease.
• Inflammatory diseases: Site-specific delivery of anti-inflammatory drugs, minimizing systemic exposure.
• Genetic disorders: Delivery of gene therapies and nucleic acid-based drugs to correct genetic abnormalities.

Contact us today to learn more about our nanoparticle development services for drug delivery systems and how we can help you bring innovative therapies to patients worldwide.