Polymer nanoparticles have revolutionized the field of drug delivery systems, offering great potential for targeted and controlled release of therapeutic drugs. Protheragen-ING specializes in the design, formulation, and optimization of innovative polymer-based nanoparticle drug delivery systems (DDSs) to meet the diverse needs of the pharmaceutical and biomedical industries.

Our team of highly skilled scientists and engineers is dedicated to pushing the boundaries of nanomedicine and exploring the vast potential of polymer nanoparticles to revolutionize therapeutics and improve patient outcomes.

About Polymer Nanoparticle DDSs

Polymer nanoparticles have emerged as a promising platform for effective and targeted delivery of various therapeutic agents, including small molecule drugs, biologics, and nucleic acids. Composed of biocompatible and biodegradable polymers, these nanoparticles are typically 10 to 200 nm in size and are carefully engineered to encapsulate, protect, and release drugs in a controlled manner.

Fig. 1 Overview of polymeric-based drug delivery systems (DDS). (Jerbic I, et al. 2018)

Polymer nanoparticles offer several key advantages that make them an attractive option for drug delivery:

• Improved solubility and stability of hydrophobic drugs.
• Targeted delivery to specific tissues or cells.
• Controlled and sustained release of the therapeutic payload.
• Enhanced permeability and retention in tumor tissues.
• Reduced systemic toxicity and side effects.
• Ability to co-deliver multiple therapeutic agents.

What We Can Offer

Protheragen-ING offers a comprehensive range of services to support the development and optimization of polymeric nanoparticles for drug delivery applications. Our dedicated team of scientists and researchers works closely with our clients to understand their specific needs and provide tailored solutions.

Our comprehensive services cover the entire spectrum of polymer nanoparticle development, from initial concept to clinical-scale production:

• Formulation design and optimization.
• Polymer selection and characterization.
• Preparation and process development of polymer nanoparticles.
• Characterization and evaluation of physicochemical properties of polymer nanoparticles.
• Surface modification strategies for polymer nanoparticles (targeting ligands, antibodies, or imaging agents affixed to the surface of the nanoparticles).
• Drug loading and encapsulation rate studies.
• In vitro and in vivo evaluation of drug release kinetics.
• Stability testing and scale-up production.

Protheragen-ING's Capabilities

Our expertise covers a wide range of polymer materials, including biodegradable and biocompatible polymers such as polyethylene glycol (PEG), polylactic acid-glycolic acid (PLGA), chitosan and polycaprolactone. We can also develop more advanced systems such as stimuli-responsive nanoparticles, targeted ligand-conjugated nanoparticles, and combination drug-carrying nanoparticles.

Fig. 2 Schematic diagram of the lipid-polymer hybrid nanoparticles. (Tahir N, et al. 2019)

Polymer Nanoparticle Preparation Technologies

We use advanced preparation techniques to create polymer nanoparticles and precisely control their properties. Our expertise includes:

• Emulsion-Solvent Evaporation.
• Nano-precipitation.
• Electrostatic Assembly.
• Solid Dispersion.

As a leading provider of polymer nanoparticle development services, Protheragen-ING is committed to pushing the boundaries of drug delivery and improving patient outcomes. Our multidisciplinary team of experts, coupled with our advanced research capabilities, enables us to develop innovative and tailored polymer nanoparticle solutions that address the unique challenges of your therapeutic application. Contact us today to learn more about how we can help you unlock the full potential of polymeric nanoparticles.