Inorganic nanoparticles, as an emerging drug delivery system (DDS) with unique physicochemical and biological properties, show great promise for targeted drug delivery, controlled release drug delivery, and improved bioavailability, etc.

Protheragen-ING focuses on harnessing the power of inorganic nanoparticles for DDSs. We offer a full range of inorganic nanoparticle drug delivery system development services and can customize inorganic nanoparticle products to meet your needs.

About Inorganic Nanoparticles DDS

Inorganic nanoparticles are promising drug delivery vehicles due to their unique properties and wide range of applications. Their sizes typically range from 1 to 100 nm, and by encapsulating drugs in these nanoparticles, we can overcome biological barriers, extend drug circulation time, and achieve site-specific delivery, ultimately leading to better therapeutic outcomes.

Fig. 1 Schematic illustrating doxorubicin loading into TLC-SPIONs. (Yu MK, et al. 2008)

Utilizing inorganic nanoparticles as a DDS has many advantages over traditional methods.

• Strong targeting: By modifying the surface of nanoparticles, selective targeting of specific cells or tissues can be achieved.
• Excellent controlled release: Nanoparticles can release drugs slowly and continuously, improving the residence time and bioavailability of drugs in the body.
• Improved solubility: Encapsulating insoluble drugs in nanocarriers can significantly improve their water solubility and bioavailability.
• High safety: Nano-scale particles can better pass through biological membranes and reduce toxic side effects on normal tissues.

Our Comprehensive Development Services

Our team of experts can assist you at every stage of the nanoparticle development process, from concept to final product. Our services include:

• Nanoparticle Design and Synthesis

We employ state-of-the-art techniques to design and synthesize inorganic nanoparticles with precise control over their size, shape, and surface properties.

• Characterization and Analysis

We utilize advanced characterization techniques to thoroughly analyze the physicochemical properties of the developed nanoparticles. This includes particle size distribution analysis, surface charge determination, morphology characterization, and drug loading efficiency assessment.

• Drug Encapsulation and Release Studies

We specialize in encapsulating various drugs within inorganic nanoparticles, ensuring efficient loading and controlled release properties. We conduct comprehensive release studies to evaluate the release kinetics, stability, and release mechanisms of the encapsulated drugs.

• Targeting Strategies and Surface Functionalization

We offer expertise in surface functionalization of inorganic nanoparticles to achieve specific targeting and enhanced cellular uptake. We can assist in the design and incorporation of targeting ligands or stimuli-responsive moieties to achieve site-specific drug delivery and controlled release at the desired location.

Types of Inorganic Nanoparticles We Can Develop

• Metal nanoparticles (e.g. gold, silver, copper, platinum, iron, etc.)
• Oxide nanoparticles (e.g. titanium dioxide, iron oxide, silicon dioxide, etc.)
• Magnetic nanoparticles (e.g. iron oxide, etc.)
• Quantum dot nanoparticles
• Carbon nanomaterials (e.g. graphene, carbon nanotubes, etc.)

Fig. 2 Different types of inorganic nanoparticles. (Li W, et al. 2019)

Inorganic Nanoparticle Preparation Technology

We have advanced preparation processes, including chemical precipitation, physical deposition, hydrothermal, sol-gel, emulsion, and microfluidization, which enable us to precisely control the size, shape, and surface properties of nanoparticles. We can also optimize the biocompatibility and functionality of nanoparticles through surface modification.

Whether you need to develop a new nano-formulation or optimize an existing process, we will do our best to provide you with professional and efficient solutions. We look forward to working with you to promote the application and development of inorganic nanotechnology in the biomedical field.