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Cat Number: API738705

Trimethoprim(TMP)

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CAS Number

738-70-5

Synonyms

Proloprim
Trimpex
Trimetoprim

Description

Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival.

Molecular Weight

290.32

Molecular Formula

C14H18N4O3

SMILES

COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N

EINECS

212-006-2

Appearance

odorless white powder

pKa

7.12 (at 20 ℃)