Cat Number: API123948878

Topotecan

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CAS Number

123948-87-8

Synonyms

Topotecan lactone
Hycamptamine
Hycamptin

Description

Topotecan is a pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an antineoplastic agent.

Molecular Weight

421.4

Molecular Formula

C23H23N3O5

SMILES

CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O

EINECS

687-471-1

Appearance

Light Yellow to Yellow Solid

Boiling Point

782.9±60.0℃ at 760 mmHg