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Cat Number: API97240794

Topiramate

CAS Number

97240-79-4

Description

Topiramate is a GluR5 kainate receptor antagonist which also inhibits Nav channels, L-type Ca2+ channels, and carbonic anhydrase

MolecularWeight

339.36

MolecularFormula

C12H21NO8S

SMILEs

CC1(OC2COC3(C(C2O1)OC(O3)(C)C)COS(=O)(=O)N)C

Appearance

Crystalline powder

Solubility

Soluble in DMSO (68 mg/ml), ethanol (68 mg/ml), methanol, water

Storage

Store at 4℃

MeltingPoint

122-125℃

BoilingPoint

~438.7℃ at 760 mmH

Density

~1.3 g/cm³

RefractiveIndex

1.5

OpticalActivity

α20D -32.5, c = 0.4 in methanol; α20D -29.98, c = 0.44 in methanol; α20D -31, c = 1 in methanol

IC50

CA II: IC50 = 5 nM (human); CA IV: IC50 = 54 nM (human); CA I: IC50 = 250 nM (human); GluR5 kainate receptors: IC50 = 0.46 µM; Carbonic anhydrase II: IC50 = 1.4 µM (rat)

pKValue

pKa: 9.22

FlashPoint

219.1±31.5 ℃

VapourPressure

0.0±1.1 mmHg at 25℃

Specification

Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches.

PreparationUse

tablets

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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