Cat Number: API481538

Tangeretin

CAS Number

481-53-8

Description

Tangeretin is a methoxyflavone compound found in citrus fruits that demonstrates antiproliferative and antioxidant effects. Tangeretin is described to block cell cycle progression at G1 in MDA-MB-435, MCF-7, and HT-29 cell lines. In human T47D cells, Tangeretin was demonstrated to inhibit ERK1/2 (extracellular-signal-regulated kinases 1/2) phosphorylation. Antioxidant activity is as reported with Tangeretin, and it was demonstrated to suppress induction of COX-2 mRNA by IL-1β and to block IL-1β-induced production of COX-2 in A549 cells.

MolecularWeight

372.4

MolecularFormula

C20H20O7

SMILEs

COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC

Appearance

Powder

Solubility

Soluble in methanol (1 mg/ml, Colorless and clear), ethyl acetate, DMSO (8 mg/ml at 25℃), water

Storage

Store at -20℃

MeltingPoint

153.0-157.0℃

BoilingPoint

565.33℃ at 760 mmHg

Density

1.24 g/cm³

RefractiveIndex

1.57

IC50

PMA-stimulated pro MMP9 production: IC50 = 6.8 µM (human); ABCG2: IC50 = 17 µM (human); P-gp expressed in A2780adr cells: IC50 = 19 µM; TNFαexpression: IC50 = 30 µM (human); TNFα-stimulated pro MMP9 production: IC50 = 33.2 µM (human)

FlashPoint

248.4±30.2 ℃

VapourPressure

0.0±1.5 mmHg at 25℃

Specification

1-98% HPLC

PreparationUse

It has been shown to combat tumor promoter-induced inhibition of cell-to-cell communication and cell proliferation in some cancer cell lines

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

INFORMATION

Tel:
E-mail:
Address:
WhatsAPP

Member of