Suplatast Tosylate

94055-76-2

Suplatast tosylate is a Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Shows antiasthmatic, anti-inflammatory and antifibrotic activity in vivo. Suplatast Tosilate (ST) is an innovative anti-allergic medication that has emerged in recent years. It is a synthetic compound known as the l-tosylate ester of suplatast, which is a novel anti-allergic substance. Suplatast Tosilate can hinder the production of pro-inflammatory cytokines, including interleukin-4 and interleukin-5. Moreover, it has also been found to suppress the activity of enzymes involved in generating inflammatory mediators such as cyclooxygenase-2 and phospholipase A2.

499.641

C23H33NO7S2

CCOCC(COC1=CC=C(C=C1)NC(=O)CC[S+](C)C)O.CC1=CC=C(C=C1)S(=O)(=O)[O-]

Powder

Soluble in water (100 mg/ml at 25℃), DMSO (100 mg/ml at 25℃), ethanol (100 mg/ml at 25℃), and methanol (very).

Store at room temperature

84-87ºC

an antiallergic drug, inhibits antigen-induced histamine release from mast cells as well as IgE antibody formation.