Sublingual tablets are an oral pharmaceutical dosage form consisting of drug ingredients and excipients. These sublingual tablets are usually flat, round, or oval in shape and are designed to be placed on the mucous membranes to allow rapid entry of the drug ingredients into the blood circulation by means of osmosis, diffusion, or dissolution. They have been widely used in the pharmaceutical field as a common form of sublingual drug delivery.

Protheragen-ING is committed to providing high-quality sublingual tablet development services to create unique sublingual delivery solutions for your products. By selecting the right ingredients and formulations, and using advanced technologies and processes, we are able to customize the development of various types of sublingual tablets to meet the specific needs of different drugs.

Benefits of Sublingual Tablets

• Rapid absorption.
• Avoidance of first-pass effect.
• Easy to carry and convenient to use.
• Reduces gastrointestinal irritation and improves patient tolerance.

Formulation Development for Sublingual Tablets

The formulation of sublingual tablets requires careful consideration of ingredients that can be rapidly dissolved and absorbed through the sublingual mucosa. Typically, the ingredients of sublingual tablets include active pharmaceutical ingredients, carrier agents, binding agents, fillers, solvents, sweeteners, etc. The proportion and selection of these ingredients play an important role in the efficacy and stability of sublingual tablets.

Protheragen-ING can tailor the composition and formulation of sublingual tablets to meet the specific requirements of different drugs. Our sublingual tablet development services cater to a wide range of therapeutic areas.

We have expertise in formulating and developing various types of sublingual tablets including:

• Rapid dissolving sublingual tablets: These tablets dissolve quickly under the tongue to allow rapid absorption of the drug.
• Controlled-release sublingual tablets: These tablets are designed with a special release technology that allows for a slow release and sustained action of the drug for an extended period of time.
• Multi-layer sublingual tablets: These tablets consist of a multi-layer structure, each layer containing different drug components, in order to realize the combination of different drugs or sequential treatment.
• Mucoadhesive sublingual tablets: These tablets possess adhesive properties that allow them to adhere to the sublingual mucosa, prolonging drug release and enhancing absorption.

Technology Used for Sublingual Tablets

Our sublingual tablet development services utilize advanced technologies to ensure the successful formulation and production of high-quality sublingual tablets.

• Direct Compression - This method involves the direct compression of a mixture of APIs and excipients into tablets, providing a cost-effective production process.
• Buccal Dispersion Technology - This technology allows the formulation of fast-dissolving sublingual tablets that disintegrate quickly in the mouth without the need for water.
• Mucosal Adhesion Polymers - These polymers are used to enhance the adhesion of sublingual tablets to mucosal surfaces, prolonging drug release and improving bioavailability.

Sublingual Tablet Manufacturing Process

1. Formulation development

Our experienced team of scientists works closely with our customers to formulate sublingual tablets according to their specific requirements to optimize drug delivery and stability.

2. Raw material preparation

Raw materials such as active pharmaceutical ingredients (APIs), carriers, binders, fillers, solvents, etc. are prepared, weighed, and mixed in the proportions specified in the formulation.

3. Pre-compression

This stage involves homogeneous mixing of APIs and excipients, followed by granulation or direct compression to form the tablet core.

4. Coating (if applicable)

Some sublingual tablets may require a coating layer to enhance stability, mask taste or provide additional functional properties.

5. Packaging

The final sublingual tablets are packaged in appropriate containers to ensure protection from moisture, light, and other environmental factors. Common forms of packaging include aluminum foil pouches, bottles, etc.

If you are interested in sublingual tablet development services or have any questions, please feel free to contact us and we will be happy to provide you with support and consultation.