Spray Drying Formulations Development
As a leading provider of pharmaceutical formulation solutions, Protheragen-ING offers spray drying formulation development services dedicated to helping customers overcome the challenges associated with difficult-to-solve aqueous molecules and difficult-to-formulate drugs. With our expertise in spray drying technology, we offer tailored formulation development services to help you achieve optimal drug solubility and bioavailability.
What is SDD?
Spray drying is a technique widely used in the pharmaceutical industry to convert liquid formulations into dry powders. It involves atomizing a liquid feed solution into a fine mist and drying it rapidly by applying hot air. The result is a dry powder with enhanced stability, improved processability, and increased surface area.
Spray-dried dispersion (SDD) refers to a specific type of formulation produced by spray drying in which the active pharmaceutical ingredient (API) is dispersed in a polymeric matrix or carrier material. SDDs are commonly used to enhance the solubility and dissolution rate of difficult-to-solubilize drugs, resulting in improved bioavailability and therapeutic efficacy.
Fig. 1 The spray-drying technique. (Sosnik A, et al. 2015)
Protheragen-ING's SSD Development Services
Our team specializes in the development of spray-dried formulations of difficult-to-solve water molecules and difficult-to-formulate drugs. We combine our scientific expertise, state-of-the-art facilities, and advanced technologies to create innovative solutions that optimize drug solubility and bioavailability. Our SDD drug platform supports a wide range of dosage forms, including tablets, capsules, powders, and granules.
Our comprehensive services include:
| Formulation design |
Our experienced scientists work closely with you to understand your drug development goals and develop a customized spray drying solution. We design optimized formulations that take into account factors such as API characteristics, target product profile, and patient needs. |
| Process optimization |
We use advanced spray drying technologies and process parameters to achieve the desired particle size, morphology, and drug-polymer interactions. Through meticulous process optimization, we ensure that the formulations developed are reproducible, scalable and manufacturable. |
| Analytical characterization |
We utilize a range of analytical techniques to evaluate the physical and chemical properties of spray-dried formulations. This includes particle size analysis, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and solubility testing to assess the solubility and stability of formulated products. |
| Scale-up and manufacturing support |
Our state-of-the-art equipment and facilities enable seamless spray drying development and manufacturing from lab scale to clinical and commercial stages. |
Experienced with all SDD polymers and solvents
- Polymers: HPMC-AS, HPMC-P, HPMC, HPC, PVP VA64, PVP, PEG, Soluplus, etc.
- Solvents: Ethanol, Acetone, Tetrahydrofuran, Methanol, Methylene chloride, etc.
Advantages of Spray-Dried Formulations
- Enhanced bioavailability of insoluble compounds.
- Consistent particle size distribution.
- Alternative to freeze-drying to stabilize biologics.
- Enhanced drug stability by converting liquid formulations into dry powders through spray drying.
- Realization of extended-release dosage forms.
- Multiple formulation dosage form options.
Contact us today to discuss your specific requirements and how we can help you achieve formulation success.
Reference
- Sosnik A, et al. (2015). "Advantages and Challenges of The Spray-drying Technology for The Production of Pure Drug Particles and Drug-loaded Polymeric Carriers." Advances in Colloid and Interface Science, 223, 40-54.
