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Cat Number: PIPE-0731

Sorafenib tosylate

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CAS Number

284461-73-0

Synonyms

Nexavar
BAY 43-9006
sorafenibum

Description

Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular carcinoma, sorafenib is also indicated to treat renal carcinoma and differentiated thyroid carcinoma.

Molecular Weight

464.8

Molecular Formula

C21H16ClF3N4O3

EINECS

608-209-4

SMILES

CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

Appearance

White solid

Storage

Room temperature