Cat Number: API475207591

Sorafenib Tosylate

CAS Number

475207-59-1

Description

Sorafenib Tosylate is an inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases used for the treatment of human hepatocellular carcinoma.

Molecular Weight

637.03

Molecular Formula

C21H16ClF3N4O3•C7H8SO3

Solubility

Soluble in water

Storage

Store at -20℃

SMILES

CC1=CC=C(C=C1)S(=O)(=O)[O-].CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

pKa

12.89

Boiling Point

523.3ºC at 760 mmHg

Density, g/cm3

1.454

IC50

Melanocortin receptor 4: IC50 = 4.48 µM (human); Raf-1: IC50 = 6 nM; B-Raf: IC50 = 22 nM; VEGFR2: IC50 = 90 nM; mVEGFR2 (flk-1): IC50 = 15 nM; mVEGR-3: IC50 = 20 nM

Melting Point

240-243℃

Flash Point

270.3ºC

Standard

Facility GMP

Preparation Use

A small molecular inhibitor of VEGFR, PDGFR, c-Raf and B-Raf, used in advanced liver cancer treatment and is well tolerated.

Qualification

ASMF/CEP/USMF

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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