Cat Number: API475207591

Sorafenib Tosylate

CAS Number

475207-59-1

Description

Sorafenib Tosylate is an inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases used for the treatment of human hepatocellular carcinoma.

MolecularWeight

637.03

MolecularFormula

C21H16ClF3N4O3•C7H8SO3

SMILEs

CC1=CC=C(C=C1)S(=O)(=O)[O-].CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

Solubility

Soluble in water

Storage

Store at -20℃

MeltingPoint

240-243℃

BoilingPoint

523.3ºC at 760 mmHg

Density

1.454 g/cm³

IC50

Melanocortin receptor 4: IC50 = 4.48 µM (human); Raf-1: IC50 = 6 nM; B-Raf: IC50 = 22 nM; VEGFR2: IC50 = 90 nM; mVEGFR2 (flk-1): IC50 = 15 nM; mVEGR-3: IC50 = 20 nM

pKValue

pKa: 12.89, pKb: 2.66

FlashPoint

270.3ºC

PreparationUse

a small molecular inhibitor of VEGFR, PDGFR, c-Raf and B-Raf, used in advanced liver cancer treatment and is well tolerated.

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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