Solid Dosage Forms Development

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Solid dosage form formulations are drug dosage forms that are present in solid form in a drug formulation. These dosage forms usually employ solid materials as carriers for the drug and are formed into solid formulations through processing and preparation processes. Protheragen-ING specializes in providing comprehensive solid dosage form formulation development services. Our experienced team of scientists and researchers is dedicated to developing high-quality formulations that meet your specific requirements. With our expertise and state-of-the-art facilities, we can assist you in formulating a wide range of solid dosage forms to bring your drug product to market successfully.

Protheragen-ING's Formulation Development Capabilities

Our formulation development capabilities cover a wide range of conventional and specialty solid dosage forms, enabling comprehensive drug formulation programs tailored to the unique properties of the molecule. Our formulation scientists are well-versed in designing formulations that optimize drug delivery and enhance therapeutic efficacy and can utilize a variety of technologies and approaches to control the release of active ingredients.

When working with Protheragen-ING, you will be able to choose from a wide range of dosage forms and release profiles, for example:

Tablets

Tablets are a mixture of drugs and excipients and are made into a solid-type dosage form by the tableting process. They are usually round or oval in shape and have a certain degree of porosity and stability.

Our experts can help you formulate tablets with precise drug content, controlled release profiles, and optimized disintegration and dissolution characteristics. We utilize advanced processes and technologies to ensure that your tablet formulations are of the highest quality and performance.

Capsules

A capsule is a solid dosage form consisting of two hollow shells filled with drugs and excipients.

Our experts specialize in the development of immediate-release and extended-release capsules. We can help you design and optimize capsule formulations to meet your specific requirements, including targeted drug release, improved stability, and enhanced bioavailability. Our state-of-the-art facilities allow us to handle a wide range of capsule sizes and fill materials.

Granules

If you require drug particles with specific sizes, shape, or surface properties, our particle engineering services can assist you. We utilize advanced particle engineering techniques, such as micronization, spray drying, and coacervation, to produce particles with controlled characteristics. Our team can also provide assistance with granule characterization and optimization for improved formulation performance.

Pellets

Pellets offer advantages such as controlled release, multiparticulate drug delivery, and improved patient compliance. Our team has expertise in developing pellets using various techniques, including extrusion-spheronization, layering, and fluid bed coating. We can tailor the pellet properties to meet your desired drug release profile and formulation requirements.

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Protheragen-ING's Full-service Capabilities

We offer a comprehensive range of services to support formulation development for solid dosage forms, covering the entire development lifecycle, from early formulation design and optimization to scale-up and commercial manufacturing.

Drug characterization	We help to understand the physicochemical properties of the drug, such as solubility, stability, and permeability, which helps to determine the appropriate formulation strategy and excipient to be used.
Excipient selection	The choice of excipient depends on factors such as drug compatibility, expected release profile, and patient considerations.
Formulation design	Factors to be considered include the desired drug release profile (immediate release, sustained release, etc.), the need for taste masking or enteric coating, and the compatibility of the drug with various excipients.
Preformulation studies	We help in evaluating the physical and chemical properties of APIs such as particle size, melting point, and polycrystalline form. These studies help identify any potential challenges in formulation development and guide formulation design decisions.
Process development	We consider factors such as mixing, granulation, compression, and coating methods to ensure consistent and reproducible production of solid dosage forms.
Stability studies	We evaluate the chemical and physical stability of drugs over time, including factors such as temperature, humidity, and light.
Analytical method development	We develop analytical methods to assess the quality and performance of solid dosage forms, including drug content uniformity, dissolution rates, and physical properties.
Regulatory support	We are well versedwell-versed in the regulations and guidelines set by regulatory agencies and can provide comprehensive regulatory support throughout the development of your solid dosage form.

Contact us today to discuss your solid dosage form formulation development requirements and learn how we can help you bring your drug to market with confidence.

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