Cat Number: PIPE-0705

Salvianolic acid A

CAS Number

96574-01-5

Synonyms

SALVIANOLIC ACID Dan Phenolic Acid A (R)-3-(3,4-Dihydroxyphenyl)-2-(((E)-3-(2-((E)-3,4-dihydroxystyryl)-3,4-dihydroxyphenyl)acryloyl)oxy)propanoic acid

Description

Salvianolic acid A is extracted from the root of Salvia miltiorrhiza Bge. It has anti-oxidative capabilities. It can reverse paclitaxel resistance through suppressing transgelin 2 expression by mechanisms involving attenuation of PI3 K/Akt pathway activation and ABC transporter up-regulation. It has inhibitory effect on Cu2+ mediated human LDL oxidation through chelating Cu2+ and scavenging free radicals. It inhibited proliferation, caused cell cycle arrest at the S phase, and induced apoptosis dose dependently to the two kinds of cancer cells. It positively regulates PTEN protein level and inhibits growth of A549 lung cancer cells.

Molecular Weight

494.4

Molecular Formula

C26H22O10

SMILES

C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=C(C(=C(C=C2)O)O)C=CC3=CC(=C(C=C3)O)O)O)O

Appearance

Powder

Storage

Room temperature

Purity

HPLC≥98%