Cat Number: API941678495

Ruxolitinib

CAS Number

941678-49-5

Synonyms

INCB018424 Ruxolitinib (INCB018424) (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Description

Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis. It has a role as an antineoplastic agent and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor.

Molecular Weight

306.4

Molecular Formula

C17H18N6

SMILES

C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

Appearance

Colorless oil

Boiling Point

592.6

Melting Point

84-89℃