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Cat Number: PIPE-0620

Rhynchophylline

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APIs
CAS Number
76-66-4
Synonyms
Rhyncophylline
Rhynchophyllin
Mitrinermin
Description
Rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and anticonvulsant activity of the Uncaira species plant extracts.Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, the present results suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia.
Molecular Weight
384.5
Molecular Formula
C22H28N2O4
EINECS
683-092-0
SMILES
CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O
Appearance
White cryst.
Storage
Room temperature
Purity
0.98
Boiling Point
560.8±50.0 ℃
Density, g/cm3
1.23±0.1
Melting Point
216 ℃
Expiration Time
2years
Applications
Antihypertension
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