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Cat Number: PIPE-0620

Rhynchophylline

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CAS Number

76-66-4

Synonyms

Rhyncophylline
Rhynchophyllin
Mitrinermin

Description

Rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and anticonvulsant activity of the Uncaira species plant extracts.Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, the present results suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia.

Molecular Weight

384.5

Molecular Formula

C22H28N2O4

EINECS

683-092-0

SMILES

CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O

Appearance

White cryst.

Storage

Room temperature