What Is Relative Density?
Relative density is defined as the ratio of a substance's density (mass per unit volume) to the density of a reference compound.
The discussion of relative density requires specifying a reference value. If the relative density of a substance is less than 1, its density is lower than the reference object; if it is greater than 1, it is denser than the reference object.
Why Measure the Relative Density of the Drug?
- Quality Control - Relative density is a fundamental parameter used to assess the quality and purity of drug substances. It provides information about the physical properties of a drug that can indicate the presence of impurities in its composition. Regulatory authorities often require the measurement of relative density as part of the drug approval process.
- Guide Production - For drugs formulated in various dosage forms such as tablets, capsules, or solutions, understanding their relative density is essential to indicate the need for specific manufacturing steps(such as densifying unit operation), ultimately leading to more efficient and reliable drug production.
- Predictive Performance - Relative density can influence a drug's solubility and bioavailability in the body. Understanding this property helps optimise drug formulations for maximum efficacy.
Services at Protheragen-ING
Initial Consultation & Planning Development
We engage in in-depth discussions with clients to ensure a thorough understanding of testing needs and objectives.
We determine appropriate reference materials (commonly water) and select measurement units, instruments, and methods based on the properties of the sample.
Sample Preparation
The collected samples undergo careful preparation to ensure their suitability for relative density testing. This step may include cleaning, drying, and other necessary procedures to eliminate potential sources of error.
We employ a range of advanced or traditional but cost-effective techniques and instruments to measure the relative density, for example:
- Pycnometers & Hydrometers - Measure the volume of the substance by comparing the change in weight when the sample is introduced into a reference liquid. It's particularly useful for solid materials and offers highly accurate results.
- Density Meters - Based on the principle of the oscillation frequency of a U-shaped vibrating element immersed in the sample liquid. Changes in the frequency are proportional to the liquid's density, allowing for precise and rapid density measurements, suitable for various sample types, including liquid and solid.
Report Delivery
We provide detailed reports containing the measured values, test temperature & humidity, and any other relevant information.
Consultation & Follow-up Support
Our experts are available for consultations, providing answers to questions about the report and insights for drug research and development. We also maintain communication with clients after delivering the report, providing support and guidance as needed.
At Protheragen-ING, our Relative Density Test service ensures that the drug development and production processes are guided by accurate, quality data.
If you have any questions or require further information, please contact us and we will respond within 2-4 working days.
