Cat Number: API112887680

Raltitrexed

Inquiry

CAS Number

112887-68-0

Synonyms

Tomudex ZD1694 ZD-1694

Description

Raltitrexed is a quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity.

Molecular Weight

458.49

Molecular Formula

C21H22N4O6S

SMILES

CC1=NC2=C(C=C(C=C2)CN(C)C3=CC=C(S3)C(=O)NC(CCC(=O)O)C(=O)O)C(=O)N1

EINECS

652-997-2

Appearance

Yellow Solid

Melting Point

176-180℃ (dec.)