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Cat Number: API1114544318

Ponatinib HCL

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CAS Number

1114544-31-8

Synonyms

Ponatinib hydrochloride;Ponatinib HCl;Iclusig;AP 24534 hydrochloride

Description

Ponatinib hydrochloride is the hydrochloride salt of ponatinib. It is a potent pan inhibitor of tyrosine kinases, active in all single resistance ABL kinase mutations including the T315l mutation. It is approved for the treatment of chronic myeloid leukemia. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It contains a ponatinib(1+).

Molecular Weight

569

Molecular Formula

C29H28ClF3N6O

SMILES

CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5.Cl

EINECS

696-530-0

Appearance

Solid powder

Standard

Facility GMP