Introduction

Plasticizer excipients are essential additives used to increase the flexibility, pliability, and processability of various pharmaceutical formulations. Plasticizers are generally high boiling point liquids and some low molecular weight polymers that can be uniformly dispersed in film forming materials. Plasticizers interact with the polymer of the film-forming material to enhance the fluidity of the polymer chains and improve the physical and mechanical properties of the film. Film-coated tablets, enteric-coated tablets, film formulations, film-coated formulations, capsules, transdermal formulations and other dosage forms generally require the addition of plasticizers.

Subtypes of Plasticizer Excipients

Phthalate Plasticizers

Phthalate plasticizers, such as diethyl phthalate (DEP) and dibutyl phthalate (DBP), have been traditionally used in the pharmaceutical industry. They provide excellent flexibility and are commonly employed in solid dosage forms, including tablets and capsules.

Citrate Plasticizers

Citrate plasticizers, such as triethyl citrate (TEC) and acetyl triethyl citrate (ATEC), are widely used as alternatives to phthalate plasticizers. They offer excellent plasticizing properties and are suitable for various dosage forms, including films, coatings, and enteric formulations.

Glycol Plasticizers

Glycol plasticizers, such as polyethylene glycol (PEG), provide outstanding mechanical properties to dosage forms. They are commonly used in liquid and semi-solid formulations, including ointments, creams, and oral suspensions.

Acetate Plasticizers

Acetate plasticizers, such as triacetin (glycerol triacetate), exhibit excellent plasticizing properties and are frequently used in oral films, transdermal patches, and gelatin capsules.

Applications

Enteric Coatings
Transdermal Patches
Oral Films
Topical Formulations

To choose plasticizer

Ideal plasticizers should meet the following requirements:

1. Colorless and odorless
2. Non-volatile
3. Thermally stable
4. Waterproof
5. Chemically stable
6. Non-migrating in the film
7. No toxic side effects

Conclusion

Pharmaceutical plasticizer excipients play a vital role in enhancing the flexibility, processability, and functionality of various pharmaceutical dosage forms. Partnering with Protheragen-ING, a reputable supplier, ensures the availability of high-quality excipients and supports the development of stable and efficacious pharmaceutical products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.