Cat Number: PIPE-0514

PHORBOL 12-MYRISTATE 13-ACETATE

CAS Number

16561-29-8

Synonyms

Phorbol 12-myristate 13-acetate
phorbol-12-myristate-13-acetate
12-O-Tetradecanoylphorbol-13-acetate
12-O-Tetradecanoylphorbol 13-acetate

Description

It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types. It has a role as a protein kinase C agonist, an antineoplastic agent, a reactive oxygen species generator, a plant metabolite, a mitogen, a carcinogenic agent and an apoptosis inducer. It is an acetate ester, a tetradecanoate ester, a diester, a tertiary alpha-hydroxy ketone and a phorbol ester.

Molecular Weight

616.8

Molecular Formula

C36H56O8

EINECS

605-413-5

SMILES

CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C

Appearance

white crystals

Storage

Room temperature