Cat Number: PIPE-0555

Phloretin

CAS Number

60-82-2

Synonyms

Dihydronaringenin
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
Phloretol

Description

Phloretin, a type of natural phenol found in the peels of apples, is a dihydrochalcone that shows beneficial effects on diabetes. Phloretin has whitening, freckle removal, anti-aging, strong antioxidant, and photoprotective effects. It can also inhibit the activity of matrix metalloproteinase (MMP-1) and elastase, which can degrade skin connective tissue and play an important role in the process of skin photoaging. Phloretin has excellent immunosuppressive and anti-inflammatory effects. Phloretin can significantly inhibit the levels of nitrogen oxide, prostaglandin E2, IL-6, TNF-α, iNOS and COX-2, inhibit the nuclear translocation of NF-JB subunit p65 protein, and reduce phosphorylation in the MAPK pathway. It can be used in facial masks, skin creams, lotions and essences.

Molecular Weight

274.27

Molecular Formula

C15H14O5

EINECS

200-488-7

SMILES

C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O

Appearance

Pearl white powder

Storage

Room temperature