Cat Number: API6493056

Pentoxyfylline

CAS Number

6493-05-6

Description

Pentoxifylline is a non-selective PDE (phosphodiesterase) inhibitor. Inhibits endotoxin-induced synthesis of tumor necrosis factor-a (TNF α). PTX inhibits the adhesion of T cells to the b1 and b2 Integrin ligands VCAM-1 and ICAM-1. Also prevents the down-regulation of microsomal cytochrome P450 caused by lipopolysaccharides.This compound is also a PDE (phosphodiesterase) inhibitor that blocks production of TNF α and other cytokines. Displays antinociceptive activity.

MolecularWeight

278.307

MolecularFormula

C13H18N4O3

SMILEs

CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C

Solubility

Soluble in water (≥43 mg/ml), chloroform, methanol, and benzene.

Storage

Store at room temperature

MeltingPoint

98-100℃

BoilingPoint

531.3±56.0 ℃ at 760 mmHg

Density

1.3±0.1 g/cm³

RefractiveIndex

1.621

IC50

interleukin-1-beta (IL1-beta) production: IC50 = >100 µM (human); Effective concentration required in vitro for tracheal muscle: EC5050 = 28.3 µM (guinea pig); TNF-alpha: IC50 = 85 µM (human)

FlashPoint

275.1±31.8 ℃

VapourPressure

0.0±1.4 mmHg at 25℃

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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