Cat Number: INT137281233

Pemetrexed

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CAS Number

137281-23-3

Synonyms

Pemetrexed disodium
Alimta
LY231514

Description

Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.

Molecular Weight

427.42

Molecular Formula

C20H21N5O6

SMILES

C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O

EINECS

680-625-9

Vapour Pressure

6X10-21 mm Hg at 25 ℃ at 25 ℃ /Estimated/

Application

Pemetrexed Disodium Intermediates

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