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Cat Number: API763113220

Olaparib

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CAS Number

763113-22-0

Synonyms

Lynparza AZD2281 AZD-2281

Description

Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2. PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Olaparib is used to treat a number of BRCA-associated tumours, including ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer.

Molecular Weight

434.46

Molecular Formula

C24H23FN4O3

SMILES

C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

EINECS

642-941-5

Appearance

White Solid Powder

Melting Point

207-210 ℃