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Cat Number: 92528ES

Noggin-1

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Genus

Human

Source

E.coli

Synonyms

NOG, SYM1, symphalangism 1 (proximal), synostoses (multiple) syndrome 1, SYNS1

Description

Noggin is a bone morphogenetic protein (BMP) antagonist expressed in Spemann's organizer. It inhibits TGF-β family ligands and preventing them from binding to their corresponding receptors.

Molecular Weight

The protein migrates as 30 KDa under reducing (R) condition (SDS-PAGE) .

Purity

> 95% as determined by SDS-PAGE.

Biological Activity

Measured by its ability to bind BMP2 with Elisa method .
Optimal concentrations should be determined by each laboratory for each application

Endotoxin

<1.0 EU per 1μg of the protein by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.

Note

10, 100μg, 1mg

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