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Cat Number: API478013

Nobiletin

CAS Number

478-01-3

Description

Nobiletin is a citrus flavonoid with anti-inflammatory, anti-cancer, cholesterol lowering, memory protection activities.

MolecularWeight

402.395

MolecularFormula

C21H22O8

SMILEs

COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC

Appearance

Powder

Solubility

Soluble in methanol, water

Storage

Store at -20℃

MeltingPoint

138 ℃

BoilingPoint

587.9±50.0 ℃ at 760 mmHg

Density

1.2±0.1 g/cm³

RefractiveIndex

1.558

IC50

ABCG2: IC50 = 4.4 µM (human); Mdr-1: IC50 = 11.5 µM (human); HT-29: IC50 = 24 µM (human); HL-60: IC50 = 41.5 µM (human); Xanthine dehydrogenase: IC50 = >100 µM (human)

FlashPoint

256.5±30.2 ℃

VapourPressure

0.0±1.6 mmHg at 25℃

PreparationUse

Inhibits the tumor invasion activity of human fibrosarcoma HT-1080 cells, not only by inhibiting the expression of MMPs, but also by impeding phosphatidylinositol 3-kinase pathway (PI3-K) to increase TIMP-1 production. Nobiletin may also prevent atherosclerosis at the wall level of blood vessels by inhibiting the formation of macrophage spongiform cells.

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Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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