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Cat Number: API2628280408

Nirmatrelvir

CAS Number

2628280-40-8

Description

(1R,2S,5S)-N-((1S)-1-Cyano-2-((3S)-2-oxopyrrolidin-3-yl)ethyl)-6,6-dimethyl-3-(3-methyl-N-(trifluoroacetyl)-L-valyl)-3-azabicyclo(3. 1.0)hexane-2-carboxamide is a synthetic antibiotic that is active against bacteria and some parasites. It has been shown to be effective in the treatment of AIDS patients infected with HIV and Mycobacterium tuberculosis. This drug also has antiviral and antifungal properties which may be due to its inhibition of viral DNA polymerase and fungal RNA polymerase.

MolecularWeight

499.5

MolecularFormula

C23H32F3N5O4

SMILEs

FC(F)(F)C(N[C@@H](C(C)(C)C)C(N1C[C@@](C2(C)C)([H])[C@@]2([H])[C@H]1C(N[C@H](C#N)C[C@H]3C(NCC3)=O)=O)=O)=O

Solubility

DMF: 2 mg/ml
DMSO: 5 mg/ml
Ethanol: 15 mg/ml
PBS (pH 7.2): insol

Storage

Store at -20℃

PreparationUse

an oral protease inhibitor with emergency use authorization for the treatment of mild-to-moderate COVID-19.