Cat Number: API21829254

Nifedipine

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CAS Number

21829-25-4

Description

Nifedipine is a selective calcium channel protein inhibitor.

MolecularWeight

346.33

MolecularFormula

C17H18N2O6

Solubility

Soluble in DMSO (50 mg/ml), acetone (250 g/L at 20℃), dichloromethane (160 g/L at 20℃), chloroform (140 g/L at 20℃), ethyl acetate (50 g/L at 20℃), methanol (26 g/L at 20℃), ethanol (17 g/L at 20℃), buffer solutions of pH4 (0.0058 g/L at 37℃), buffer solutions of pH7 (0.0056 g/L at 37℃), buffer solutions of pH9.0 (0.0078 g/L at 37℃), and buffer solutions of pH13 (0.006 g/L at 37℃). Insoluble in water.

Storage

Store at room temperature

MeltingPoint

173-177℃

RefractiveIndex

1.56

IC50

Voltage-gated L-type calcium channel alpha-1C subunit: IC50 = 1 nM (Oryctolagus cuniculus); Rattus norvegicus: IC50 = 1.16 nM (Rattus norvegicus); Oryctolagus cuniculus: IC50 = 0.5 nM (Oryctolagus cuniculus); Voltage-gated L-type calcium channel alpha-1D subunit: IC50 = 2.5 nM (human); Aorta: IC50 = 9 nM (Cavia porcellus); Sus scrofa: IC50 = 3.6 nM (Sus scrofa); Cavia porcellus: IC50 = 4 nM (Cavia porcellus); Voltage-gated L-type calcium channel alpha-1C subuni: IC50 = 2.53 nM (Rattus norvegicus); Rattus norvegicus: EC5050 = 3.2 nM (Rattus norvegicus); Transient receptor potential cation channel subfamily A member 1: EC5050 = 400 nM (Mus musculus)

pKValue

pKb: 2.69

Specification

Calcium channel blockers

PreparationUse

Nifedipine tablets (5 mg, 10 mg)

Standard

Chinese Pharmacopoeia 2015 Edition Part 2

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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