Cat Number: API95734820

Nedaplatin

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CAS Number

95734-82-0

Synonyms

Aqupla
NSC 375101D
azane;2-hydroxyacetic acid;platinum

Description

Nedaplatin is a second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.

Molecular Weight

305.2

Molecular Formula

C2H10N2O3Pt

SMILES

C(C(=O)O)O.N.N.[Pt]

Appearance

White powder or crystalline powder

Standard

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