Nasal Spray Development Services
Nasal sprays are liquid formulations that are a popular and effective method of delivering medication directly into the nasal passages. It releases a fine mist of medication into the nasal passages. The mist is then inhaled, allowing the medication to be absorbed through the nasal mucosa and into the bloodstream. It is a convenient and non-invasive way of administering medication that allows for rapid absorption and targeted delivery. Nasal sprays are commonly used for a variety of purposes, including allergy relief, nasal congestion, pain management, and hormone therapy.
Protheragen-ING is committed to providing high-quality nasal spray development solutions to meet specific customer requirements. With our expertise in formulation development, process optimization, and regulatory compliance, we can help you turn your nasal spray product idea into reality.
Key Benefits of Nasal Sprays
Nasal sprays offer several advantages as a route of administration.
- Targeted drug delivery - delivering the drug directly to the nasal cavity.
- Rapid onset of action - large surface area of the nasal mucosa with abundant blood flow facilitates rapid absorption and distribution of the drug.
- Easy to use - providing convenient self-administration.
- Localized administration - reducing systemic side effects.
- Non-invasive drug delivery.
- Improve patient compliance.
- Also suitable for systemic administration.
- Versatility to customize nasal spray formulations.
Formulation Properties of Nasal Sprays
The parameters that affect the ease of atomization of the formulation will have the greatest impact on the spray properties. We carefully consider the following attributes during development.
- Viscosity - The viscosity of a nasal spray solution affects its flow and spray characteristics. It determines the ease of delivery and the amount of drug administered per dose.
- Surface Tension - The surface tension of a formulation affects droplet size and distribution. It plays an important role in the deposition of drug in the nasal cavity and affects its absorption.
- Density - The density of a nasal spray formulation affects particle settling and the overall stability of the product. It is important to maintain a consistent density to ensure uniform dosing.
- Particles - The size and distribution of particles in a nasal spray formulation affects its performance. Fine particles are ideal for optimal deposition in the nasal tract, while large particles may cause irritation.
Classification of Nasal Sprays
Protheragen-ING specializes in the development of various types of nasal sprays. The choice of formulation depends on the solubility of the drug and the desired therapeutic effect. We offer the following formulation classifications:
a. If the API is soluble in water, an aqueous solution is preferred. Our team of experts can develop stable and effective aqueous nasal spray formulations that ensure accurate dosing and rapid absorption.
b. If the API is relatively insoluble in water, we will explore alternative formulation options. These can include aqueous suspensions, aqueous alcohol or cosolvent formulations, or non-aqueous systems.
Our formulation scientists have extensive experience in developing these complex formulations to optimize drug solubility and stability.
Nasal Spray Preparation Process
Our comprehensive nasal spray development process encompasses formulation design, laboratory-scale development, and manufacturing scale-up. We employ state-of-the-art technologies and adhere to stringent quality standards to ensure the production of safe and effective nasal spray products.
Our team of experts conducts thorough research and development, evaluating various excipients, preservatives, and drug delivery systems. We optimize formulation parameters to achieve the desired drug release profile, stability, and patient acceptability. Our scientists collaborate closely with clients to tailor the nasal spray formulation to their specific requirements.
Development of Preservative-free Nasal Sprays
We understand the growing demand for preservative-free nasal spray products. To meet this demand, our highly skilled formulation team specializes in developing preservative-free nasal formulations.
We comply with USP <797> by using innovative technologies and alternative preservative systems to ensure product safety and stability while minimizing the potential adverse effects associated with preservatives.
Our Services
We offer a range of services to support your nasal spray product development needs.
- Formulation optimization and reformulation.
- Stability testing and evaluation.
- Product testing.
- In vitro bioequivalence testing.
- Drug and delivery assays.
- Structural analysis of drug-related impurities and degradation products.
- Extractables and leachable studies.
- Compatibility studies.
- Regulatory support and documentation.
- Analytical method development.
- Manufacturing process optimization.
- Packaging development and design.
Contact us today to discuss your project and learn how we can help you bring your nasal spray innovation to market.
