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Cat Number: API70476823

Mitoxantrone hydrochloride

CAS Number

70476-82-3

Description

Mitoxantrone dihydrochloride is a topoisomerase II inhibitor; also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM.

MolecularWeight

517.403

MolecularFormula

C22H30Cl2N4O6

SMILEs

C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl

Solubility

Soluble in water (89 mg/ml at 25℃), 100% ethanol (slightly), methanol (slightly), and DMSO (89 mg/ml at 25℃). Insoluble in acetone.

Storage

Store at -20℃

MeltingPoint

203-205ºC

BoilingPoint

805.7ºC at 760 mmHg

RefractiveIndex

~1.71

IC50

Type II topoisomerase : IC50 = 50 nM

PreparationUse

is used to traet acute nonlymphocytic leukemia, including myelogenous promyelocytic, monocytic, and erythroid acute leukemias.

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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