Description
Minocycline, Hydrochloride is a broad-spectrum tetracycline antibiotic that also acts as PARP inhibitor.
MolecularFormula
C23H27N3O7•HCl
SMILEs
CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=O)/C(=C(/N)\\O)/C1=O)O)O)O)N(C)C.Cl
Solubility
Soluble in DMSO (7 mg/ml), water (50 mg/ml), methanol, and aqueous solutions of alkali hydroxides and carbonates.
BoilingPoint
659.4ºC at 760mmHg
OpticalActivity
α20D -175, c = 0.5 in 0.1ml/L HCl
IC50
Plasmodium falciparum W2: IC50 = 794.33 nM
pKValue
pKa: 4.5, pKb: 11.06
VapourPressure
6.33E-28mmHg at 25℃
Specification
Second generation tetracycline antibiotic. Antibacterial and antiinflammatory
PreparationUse
ER tablets