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Cat Number: API84371653

Mifepristone

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CAS Number

84371-65-3

Description

Mifepristone is a progesterone and glucocorticoid antagonist, suppresses VEGF production.

MolecularWeight

429.59

MolecularFormula

C29H35NO2

SMILEs

CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O

Appearance

Powder

Solubility

Soluble in water (partly), DMF (~30 mg/ml), ethanol (50 mg/ml), methanol, and DMSO (86 mg/ml at 25℃).

Storage

Store at 4℃

MeltingPoint

192-196℃

BoilingPoint

628.61℃ at 760 mmHg

Density

1.19 g/cm³

RefractiveIndex

1.62

OpticalActivity

α20D +149, c = 0.55 in chloroform

IC50

Progesterone receptor: IC50 = 0.2 nM; PR dimerization and activation: IC50 = 0.6 nM; Glucocorticoid receptor: IC50 = 2.6 nM; ovarian cancer cell growth of SK-OV-3: IC50 = 6.25 µM; ovarian cancer cell growth of OV2008: IC50 = 6.91 µM

pKValue

pKa: 12.94, pKb: 5.49

FlashPoint

334.0±31.5 ℃

VapourPressure

0.0±1.9 mmHg at 25℃

PreparationUse

orally-active progesterone and glucocorticoid receptor antagonist indicated for use as a post-coital contraceptive.

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Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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