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Cat Number: CHE120685112

Midostaurin

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CAS Number

120685-11-2

Synonyms

PKC412
Cgp 41251
PKC-412

Description

Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors. It was approved on April 28, 2017 and has shown to increase the overall survival rate in patients with AML as an adjunct therapy along with chemotherapeutic agents.

Molecular Weight

570.6

Molecular Formula

C35H30N4O4

SMILES

CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC

EINECS

848-383-0

Appearance

Light Yellow to Yellow Solid

Density, g/cm3

1.47±0.1 (Predicted)