Microparticle Depots Design and Development Services

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Microparticle depots have emerged as a breakthrough technology for drug delivery systems. These tiny biocompatible carriers control the release and targeted delivery of drug compounds for precise dosing and prolonged therapeutic effects. Protheragen-ING is focused on harnessing the power of microparticles to revolutionize drug delivery systems.

We offer comprehensive design and development services for microparticle depots that enhance therapeutic efficacy while ensuring patient comfort and convenience. By encapsulating drugs in microparticles, we can overcome challenges such as rapid drug degradation, poor bioavailability, and inconvenient routes of administration. Whether you are in the pharmaceutical industry, R&D, or academia, we are ready to work with you to bring your particulate reservoir idea to life.

About Microparticle Depots

Microparticle depots are drug delivery systems that utilize tiny particles to encapsulate and release therapeutic agents in a controlled manner. These particles can be in the form of matrix-like microspheres or microcapsules with a unique core/shell structure. Their size is typically in the micrometer or nanometer range and can be composed of a variety of materials, such as biodegradable polymers, lipids, or inorganic substances. Once formulated, the microparticles are typically lyophilized or freeze-dried to produce a stable dry powder, which remains in a dry state until they are mixed with a diluent prior to administration.

Fig.1 Overview schematic of iLN microparticle depot strategy to promote tolerance in T1D and allogenic islet transplantation Intra-lymph node. Fig. 1 Overview schematic of iLN microparticle depot strategy to promote tolerance in T1D and allogenic islet transplantation Intra-lymph node (iLN). (Gammon J.M, et al. 2023)

Microparticle depots offer several advantages over traditional drug delivery methods:

Extends drug release time.
Provides drug protection and stability.
Targeting specific tissues or cells.
Versatility in drug loading.

Our Microparticle Depot Services

Protheragen-ING is passionate about developing innovative microparticle depots that can revolutionize drug delivery. Our comprehensive design and development services, combined with our multidisciplinary expertise, make us the ideal partner for your microparticle depot project.

Below are the microparticle depo design and development services we can offer:

Customized Microparticle Formulation: We offer tailored microparticle formulation services to meet your specific drug delivery requirements. Our experts will work closely with you to understand your drug's characteristics, target site, and desired release profile. Using advanced techniques, we will develop a customized formulation that optimizes drug encapsulation, stability, and release kinetics.
Design Optimization: Our team excels in designing microparticle depots with enhanced functionality. We employ state-of-the-art computational modeling and simulation tools to optimize the shape, size, and surface properties of microparticles. Through meticulous design optimization, we aim to maximize drug loading capacity, prolong release duration, and achieve precise targeting of the desired site of action.
Controlled Release Systems: We specialize in the development of controlled-release microparticle depots. By incorporating innovative drug release mechanisms, such as diffusion, degradation, or stimuli-responsive properties, we can tailor the release kinetics to match your therapeutic needs. Our controlled release systems ensure sustained drug delivery, minimizing the frequency of administration and enhancing patient compliance.

Fig.2 Controlled Release Systems.

Items	Descripcion	Details
Microsphere	Microspheres are spherical particles that encapsulate drugs and offer unique advantages in drug delivery.	Microsphere formulation - Microspheres of precise size, morphology, and drug encapsulation efficiency. Microsphere surface modification Facilitating targeted drug delivery. Biodegradable microspheres. Microsphere physical and chemical property characterization.
Microcrystal	Microcrystals offer unique advantages as drug delivery systems, especially for difficult-to-solve drugs.	Various crystallization techniques - Production of microcrystals with desired properties such as size, shape, and polymorphism. Particle engineering - optimizing microcrystal properties to improve dissolution rates, bioavailability, and stability. Coating and Encapsulation Services - Protecting microcrystals, enhancing their drug release behavior, and enabling targeted delivery. In vitro and in vivo evaluations - assessing the performance, pharmacokinetics, and therapeutic efficacy of microcryst.

Reference

Gammon J.M, et al. (2023). "Engineering The Llymph Node Environment Promotes Antigen-specific Efficacy in Type 1 Diabetes and Islet Transplantation." Nature Communications, 14, 681.

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