Description
Metronidazole is an antibiotic affective against protozoa and anaerobic gram-positive and gram-negative bacteria.
MolecularFormula
C6H9N3O3
Appearance
Crystalline powder
Solubility
Soluble in water (10 mg/ml at 20℃), ethanol (5 mg/ml), methanol, chloroform
MeltingPoint
159-161℃ (lit.)
BoilingPoint
405.4±25.0 ℃ at 760 mmHg
IC50
Trichomonas vaginalis: IC50 = 0.21 µM; Entamoeba histolytica: IC50 = 0.35 µM; Giardia intestinalis: IC50 = 0.1 µg/ml; HeLa: IC50 = >1000 µg/ml (human)
pKValue
pKa: 2.38, pKb: 2.58
VapourPressure
0.0±1.0 mmHg at 25℃
Specification
a nitroimidazole antibiotic
PreparationUse
tablets, vaginal effervescent tablets