Cat Number: API59052

Methotrexate

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CAS Number

59-05-2

Synonyms

Rheumatrex
Amethopterin
Methylaminopterin

Description

Methotrexate is a member of pteridines, a monocarboxylic acid amide and a dicarboxylic acid. It has a role as an antineoplastic agent, an antirheumatic drug, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, a DNA synthesis inhibitor, an abortifacient, a dermatologic drug, an antimetabolite and an immunosuppressive agent.

Molecular Weight

454.4

Molecular Formula

C20H22N8O5

SMILES

CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

EINECS

200-413-8

Appearance

odorless yellow to orange-brown crystalline powder.

Melting Point

185-204 ℃