Marinosomes Development Services

Protheragen-ING focuses on the development and optimization of marinosomes, cutting-edge lipid vesicles derived from marine organisms. With our expertise and state-of-the-art facilities, we offer comprehensive development services to pharmaceutical companies, researchers, and biotechnology companies seeking advanced drug delivery systems. Whether you are looking to enhance drug stability, improve bioavailability, or target specific tissues, we are committed to helping you harness the potential of marinosomes for your therapeutic applications.

Marinosomes: An Overview

Marinosomes are liposomes based on natural marine lipid extracts containing a high proportion of polyunsaturated fatty acids (PUFA) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). They are not present in the normal skin epidermis but are metabolized and stored in cell membrane phospholipids. These lipid-based vesicles are derived from marine organisms and offer a unique advantage for delivering therapeutic compounds. By encapsulating drugs in marinosomes, we can enhance their stability, control release kinetics, and improve their interaction with target cells.

Fig. 1 Structure of marine phospholipids-EPA AND DHA. (Deepthi KL, et al. 2021)

• Marinosomes mimic the natural properties of cell membranes, making them highly biocompatible and suitable for a wide range of drug formulations.
• The structural flexibility of marinosomes allows for the encapsulation of hydrophilic and hydrophobic drugs within their aqueous core or lipid bilayer, respectively.
• The surface properties of marinosomes can be modified through surface functionalization to enable targeted drug delivery and improved cellular uptake.

Protheragen-ING's Development Services

We offer comprehensive development services to utilize the potential of marinosomes for your specific drug delivery needs. Our commitment to compliance ensures that our services meet industry best practices and regulatory requirements.

Our services include:

• Formulation development

We work closely with you to design and optimize marinosome formulations for your drug candidates. Our experts use cutting-edge technologies to achieve optimal drug loading, stability, and release profiles.

• Drug encapsulation

We have extensive experience in encapsulating a wide range of drugs within marinosomes, including small molecules, peptides, proteins, and nucleic acids. Our expertise ensures effective encapsulation and preservation of drug activity.

• Surface modification and targeting

We employ a variety of surface modification strategies to functionalize marinosomes for targeted drug delivery. Whether you need ligand coupling, antibody targeting, or stimuli-responsive systems, we can customize marinosomes to meet your specific requirements.

• In vitro and in vivo evaluation

Our team performs rigorous characterization and evaluation of marinosomes to assess their physicochemical properties, release kinetics, cellular uptake and therapeutic efficacy. We utilize advanced analytical techniques and cell-based assays to provide comprehensive data for your drug development process.

Fig. 2 Curcumin marinosomes as promising nano-drug delivery system for lung cancer. (Ibrahim S, et al. 2018)

Our Advantages

The marinosomes drug delivery system we developed offers several key advantages:

• Enhanced drug stability - It protects encapsulated drugs from degradation, enzymatic activity, and harsh physiological conditions.
• Improved drug bioavailability - The unique structure of Marinosomes facilitates efficient drug absorption and uptake.
• Controlled release kinetics - By modifying the composition and structure of Marinosomes, we can customize the release kinetics of the drug.
• Targeted drug delivery - Surface functionalization of Marinosomes allows for specific targeting of diseased tissues or cells.

Contact us today to explore how Marinosomes can revolutionize your drug delivery strategies and bring new possibilities to your pharmaceutical endeavors.