Cat Number: API491703

Luteolin

CAS Number

491-70-3

Description

Luteolin is an inhibitor of LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocker of NF-κB and AP-1 activation.

MolecularWeight

286.24

MolecularFormula

C15H10O6

SMILEs

C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O

Appearance

Powder

Solubility

Soluble in aqueous alkaline solutions (1.4 mg/ml), ethanol (~5 mg/ml), DMSO, 1eq. NaOH (5 mM), DMF (~20 mg/ml), 1:5 solution of DMF:PBS(pH7.2) (`~1 mg/ml), water (1 mg/ml at 25℃), and methanol.

Storage

Store at 4℃

MeltingPoint

330℃ (lit.)

BoilingPoint

~616.1℃ at 760 mmHg

Density

~1.7 g/cm³

RefractiveIndex

1.77

IC50

soybean and reticulocyte 15-lipoxygenases: IC50 = 0.6 µM; HIV-1(IIIB): IC50 = 16 µM (H9); HIV-1(IIIB): EC5050 = 10 µM (H9); Cyclooxygenase-2: IC50 = 2.5 ug.mL-1 (human); Cytochrome P450 1B1: IC50 = 79 nM (human); Xanthine dehydrogenase: IC50 = 550 nM (human); Dopamine transporter: EC5050 = 1450 nM (rat); H9c2 : EC5050 = 5530 nM (rat)

pKValue

pKa: 6.50

FlashPoint

239.5±25.0 ℃

VapourPressure

0.0±1.8 mmHg at 25℃

Specification

90-95% HPLC

PreparationUse

anti-inflammatory, antioxidant, anti-cancer

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed