What Are LogP, LogD, and pKa?
LogP, LogD, and pKa are essential chemical parameters that are used to characterise drug molecules.
- LogP stands for the logarithm of the partition coefficient, which is the ratio of the solute concentration between two solvents. It represents the logarithm of the partition coefficient of a drug molecule between n-octanol and water. This value reflects the drug's lipophilicity, with higher logP values indicating a greater ability of the drug to pass through biological barriers and enter cells or target organs.
- LogD, or the logarithm of the distribution coefficient, is a measure of a drug molecule's partition coefficient at different pH values. It provides insights into the drug's charge state and solubility across different pH conditions. LogD values vary with pH and are useful for assessing how a drug will distribute in various physiological environments.
- pKa represents the negative logarithm of Ka, where Ka stands for the Acid Dissociation Constant. This constant quantifies the strength of an acid in a solution and measures the extent to which an acid dissociates into protons and a conjugate base. The pKa values reflect the acidity or alkalinity of a drug, which is crucial for determining the optimal drug delivery form.
LogP, LogD, and pKa are fundamental parameters in the characterisation of drug molecules.
They are of significant importance in pharmacokinetics (PK) research and are integral to evaluating how clinical candidate molecules are absorbed, distributed, metabolized and excreted (ADME) within the body.
These parameters are key indicators of a drug's potential and impact the entire process of new drug development.
Services at Protheragen-ING
Initial Consultation
We begin the process with a detailed consultation to understand the specific needs. During this phase, we will collect information about the purity, stability, desired pH conditions and any additional project requirements.
Project Planning
Our team of experts will assist in selecting the most appropriate method for characterizing the compound. Then we will create a project schedule to ensure transparency and feasibility, which will be provided to the client.
This helps clients understand the timeline of the entire analysis process, ensuring the project proceeds as planned.
Analysis
We conducted the analysis using advanced techniques and instrumentation, including techniques such as spectrophotometry, potentiometric titration, and HPLC.
Reporting and Follow-up Support
We provide clients with a comprehensive report detailing the analysis results, methodology used and test conditions.
If customers require it, our experts in the field of pharmaceutical analysis will interpret the results and provide valuable insights into these values of drug molecules. This information is essential for understanding the drug performance in different physiological conditions.
If you are interested in this service and wish to learn more, please contact us. Protheragen-ING is ready to provide guidance and recommendations for clients around the world. We will respond promptly, typically within 2-4 business days.
