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Cat Number: API851199592

Linaclotide

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CAS Number

851199-59-2

Synonyms

Linzess
Constella
UNII-N0TXR0XR5X

Description

Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist. Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C.

Molecular Weight

1526.8

Molecular Formula

C59H79N15O21S6

SMILES

CC1C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)CNC(=O)C(NC2=O)C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)O)C(=O)NC(CSSCC(C(=O)N3)N)C(=O)NC(C(=O)N5CCCC5C(=O)N1)CC(=O)N)CC6=CC=C(C=C6)O)CCC(=O)O

EINECS

812-291-9

Appearance

White to off-white powder

Boiling Point

2045.0±65.0℃(Predicted)

Density, g/cm3

1.6

Melting Point

231-235℃

Specification

Technical Package