Synonyms
IRINOTECAN HYDROCHLORIDE Trihydrate
Camptosar
Irinotecan Hcl Trihydrate
Campto
Description
A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.
Molecular Formula
C33H45ClN4O9
SMILES
CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl
Appearance
Pale yellow to yellow crystalline solid
Melting Point
>245℃ (dec.)