Cat Number: API220127571

Imatinib Mesylate

CAS Number

220127-57-1

Description

Imatinib mesylate is a c-Abl, PDGFR, and c-kit inhibitor that halts chronic myelogenous leukemia related growth.

MolecularWeight

589.71

MolecularFormula

C29H31N7O•CH3SO3H

SMILEs

O=S(O)(C)=O.O=C(NC1=CC=C(C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C)C4=CC=C(CN5CCN(CC5)C)C=C4

Appearance

Crystalline powder

Solubility

Soluble in water (200 mg/ml), ethanol (~0.2 mg/ml), DMSO (200 mg/ml), DMF (~10 mg/ml), and methanol (sparingly).

Storage

Store at 4℃

MeltingPoint

214-224℃

RefractiveIndex

1.67

IC50

PDGFR: IC50 = 0.1 µM; c-Kit: IC50 = 0.1 µM; K562 cells : IC50 = 0.21 µM (human); v-Abl: IC50 = 0.6 µM

PreparationUse

Anti-cancer

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

INFORMATION

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