Cat Number: API123663-49-0

Iguratimod

CAS Number

123663-49-0

Description

Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.

MolecularWeight

374.37

MolecularFormula

C17H14N2O6S

Storage

Store at 4℃

MeltingPoint

237-242℃

BoilingPoint

580.6±60.0 ℃ at 760 mmHg

Density

1.52 g/cm³

RefractiveIndex

1.674

FlashPoint

304.9±32.9 ℃

VapourPressure

0.0±1.6 mmHg at 25℃

PreparationUse

anti-inflammatory. Reduces the production of prostaglandins in inflammatory tissues by selective inhibition of cyclooxygenase-2; Inhibits the release of bradykinin from inflammatory tissues; Inhibit antigen-specific T cell proliferation; Reduces the level of pro-inflammatory factors produced by B cells in patients with rheumatoid arthritis; stimulates osteoblast differentiation and bone construction; Inhibits synovial cell co-stimulatory factor expression and cytokine production.

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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