Cat Number: INT134978975

H2N-PEG2-CH2COOH / (H-AEEA-OH)

CAS Number

134978-97-5

Synonyms

2-(2-(2-Aminoethoxy)ethoxy)acetic acid
2-[2-(2-aminoethoxy)ethoxy]acetic acid
8-Amino-3,6-dioxaoctanoic acid
H2N-PEG2-CH2COOH

Description

H2N-PEG2-CH2COOH belongs to a polyethylene glycol (PEG) linker covalently bound to E3 Ligase binding group (E3LB) and protein binding group (PB). H2N-PEG2-CH2COOH is a PEG derivative containing an amino group with a terminal carboxylic acid. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. PEG Linkers may be useful in the development of antibody drug conjugates and PROTACs.

Molecular Weight

163.17

Molecular Formula

C6H13NO4

EINECS

810-220-6

SMILES

C(COCCOCC(=O)O)N

Appearance

White Powder

Boiling Point

323.8 ℃ at 760 mmHg