Cat Number: API107007998

Granisetron hydrochloride

CAS Number

107007-99-8

Description

Granisetron Hcl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

MolecularWeight

348.87

MolecularFormula

C18H24N4O•HCl

SMILEs

CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl

Solubility

Soluble in DMSO (100 mM), water (70 mg/ml at 25℃), ethanol (1 mg/ml at 25℃), and methanol.

Storage

Store at room temperature

MeltingPoint

284.0-290.0℃

BoilingPoint

532℃ at 760 mmHg

RefractiveIndex

1.69

IC50

NG108-15: IC50 = 2.8 nM (Murinae); Dopamine D2 receptor: IC50 >1 µM (rat); Serotonin 4 (5-HT4) receptor: IC50 >1 µM (guinea pig); Serotonin 3 receptor: IC50 = 1.76 µM (rat)

FlashPoint

275.6ºC

VapourPressure

0mmHg at 25℃

PreparationUse

selective antagonist of the 5-serotonin 3 (5-HT3) in peripheral and central nervous system, used as an antiemetic.

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

INFORMATION

Tel:
E-mail:
Address:
WhatsAPP

Member of