Protheragen-ING understands the importance of ensuring the safety and quality of cosmetic products. That's why we offer comprehensive glucocorticoid testing, specifically designed to detect the presence of glucocorticoids in cosmetic formulations.
Our state-of-the-art testing facilities and experienced team of experts are dedicated to providing accurate and reliable results to ensure the safety and compliance of your cosmetic products.
Understanding Glucocorticoids
Glucocorticoids are a class of steroid hormones produced naturally by the body's adrenal glands. They play a crucial role in regulating a variety of body functions, including immune response, metabolism and inflammation.
In cosmetics, glucocorticoids are sometimes added to products for their anti-inflammatory properties, which help relieve skin conditions such as eczema, dermatitis and psoriasis.
Testing Implications
While glucocorticoids can provide beneficial effects when used correctly, misuse or overuse in cosmetics can lead to potential health risks. Excessive and prolonged exposure to glucocorticoids can lead to thinning of the skin, increased vascularity and other adverse reactions.
It is critical for cosmetic manufacturers to ensure that the levels of glucocorticoids in their products meet regulatory guidelines and do not pose a risk to consumer safety.
Comprehensive Testing Services
Protheragen-ING keeps a close eye on developments and hot issues in the cosmetics industry and has been helping to improve product safety and quality indicators, working with you to verify the quality of your products.
We perform 71 tests for the presence and concentration of glucocorticoid-like substances in cosmetic samples. Below is a selection of our test items.
| Quincy Long |
Cortisone |
Flumethasone |
Methylprednisone (MPN) Prednisone |
| Prednisolone |
Methylprednisolone |
Beclomethasone |
Methylprednisone acetate (MPNA) |
| Hydrocortisone |
Betamethasone |
Trimethoprim |
Aclomethasone dipropionate |
| Prednisone |
Dexamethasone |
Fludioxonil |
Betamethasone valerate |
| Desoximetasone |
Licorcetophenol |
Triamcinolone acetonide |
Prednicarbate |
| Flunitrazone |
Fluocortolone |
Prednisolone acetate |
Hasinide |
Test Procedure
Our glucocorticoid test method involves a series of analytical techniques to detect and quantify the presence of glucocorticoids in cosmetic products.
Sample Collection
Testing samples may involve taking a small portion of the product or extracting specific ingredients as required.
Protheragen-ING provides detailed instructions on how to collect and submit samples for testing.
Sample Extraction
Protheragen-ING utilizes a variety of extraction techniques to extract glucocorticoids from samples.
Common methods include solvent extraction, solid phase extraction (SPE), liquid-liquid extraction (LLE), or a combination of these methods. The choice of extraction method depends on the characteristics of the cosmetic and the target glucocorticoid.
Purification
Techniques such as solid phase microextraction (SPME) or liquid chromatography can be used to remove impurities and concentrate glucocorticoids.
Instrumental Analysis
Protheragen-ING uses sophisticated equipment for the instrumental analysis of purified samples.
Liquid chromatography-mass spectrometry (LC-MS) is a popular technique for the identification and quantification of glucocorticoids due to its high sensitivity and selectivity.
Depending on the specific requirements of the analysis, other techniques such as gas chromatography (GC) or immunoassay may also be used.
Calibration and Quantification
To determine the concentration of glucocorticoids in a sample, a calibration curve is generated using known standards of the target compound.
These standards cover a range of concentrations to establish a relationship between concentration and analytical instrument response. The concentration of glucocorticoids in the sample is then calculated from the calibration curve.
Report
The report typically includes the concentration of glucocorticoids detected in the sample, any relevant qualitative information, and a summary of the test method used. The report can also provide regulatory compliance guidance and recommendations based on the results.
Contact Protheragen-ING today to discuss your testing requirements to determine the best test method for your specific needs. We will respond within 2-4 working days.
