Cat Number: API59870687

Glabridin

CAS Number

59870-68-7

Description

Glabridin is an isoflavan that improves mitochondria function. It has been shown to stimulat DNA synthesis in human endothelial cells. Glabridin also has been shown to have a bi-phasic effect on proliferation of human vascular smooth muscle cells.

MolecularWeight

324.37

MolecularFormula

C20H20O4

SMILEs

CC1(C=CC2=C(O1)C=CC3=C2OC[C@H](C3)C4=C(C=C(C=C4)O)O)C

Solubility

Soluble in DMSO (≥14 mg/ml).

Storage

Store at -20℃

MeltingPoint

154-155ºC

BoilingPoint

518.6±50.0 ℃ at 760 mmHg

Density

1.3±0.1 g/cm³

RefractiveIndex

1.623

IC50

PTP1B : IC50 = 73.4 µM (human)

pKValue

pKa: 9.66

FlashPoint

267.4±30.1 ℃

VapourPressure

0.0±1.4 mmHg at 25℃

PreparationUse

shows a strong anti-free radical oxidation effect in The cytochrome P450/NADPH oxidation system, which can significantly inhibit the free radicals generated during metabolism in the body, so as to avoid oxidation-sensitive biological macromolecules (LDL, DNA) and cell wall oxidative damage by free radicals. Thus, it can prevent and treat certain pathological changes related to free radical oxidation, such as atherosclerosis, cellular aging, etc.

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