Pharmaceutical gels consist of small or large-molecule, drugs dispersed in a gel-like medium to make viscous liquid or semi-solid formulations of solutions, suspensions or emulsions. These gels are widely used in the pharmaceutical industry due to their unique properties of ease of use, controlled release, and improved drug delivery. Pharmaceutical gels provide a versatile platform for the development of a wide range of drug products, including topicals, transdermal patches, ophthalmic formulations, and oral gels.
Protheragen-ING specializes in providing comprehensive pharmaceutical gel development services to meet the unique needs of customers in the healthcare and pharmaceutical industries. With our expertise in formulation science, advanced technology,s, and regulatory compliance, we provide end-to-end solutions for the development, optimization, and manufacturing of pharmaceutical gels.
Benefits of Gels
- Provide controlled release mechanism for enhanced drug delivery.
- Have superior skin permeability for enhanced topical delivery.
- Easy to apply and non-greasy, improving patient compliance.
- Protects the drug from degradation, oxidation and other environmental factors for improved stability.
- Multifunctional formulation containing multiple active pharmaceutical ingredients.
We offer a wide range of gel types:
- Semisolid Dispersion of Drug in a Hydrophilic or Hydrophobic Base
This type of gel consists of a drug dispersed within a semisolid base, which can be hydrophilic (water-loving) or hydrophobic (water-repellent).
Hydrogels are three-dimensional networks of hydrophilic polymers that can absorb and retain large amounts of water.
Non-aqueous gels are formulated using non-aqueous solvents, such as oils or organic liquids, as the gel base. They are often used to deliver drugs that are not stable or soluble in water-based systems.
Organogels are gels formed by dispersing organic compounds, such as lipids or organic polymers, in an organic solvent or oil. They are frequently used in topical drug delivery, especially for lipophilic drugs.
Thermosensitive gels are liquid at lower temperatures but undergo gelation or solidification upon exposure to body temperature. They can be administered as a liquid, which transforms into a gel upon contact with the skin or mucosal surfaces.
pH-sensitive gels undergo a reversible gelation or sol-gel transition in response to changes in pH. They can be designed to respond to the specific pH conditions of different body sites, such as the stomach, intestine, or vagina.
Methods for Preparation of Ges
The preparation of our pharmaceutical gels involves several steps including:
- Selection of a suitable polymer and solvent based on the desired properties of the final gel formulation.
- Dissolving or dispersing the polymer in the selected solvent to form the gel matrix.
- Incorporating the active pharmaceutical ingredient into the gel matrix by mixing or homogenization.
- If desired, add other excipients such as preservatives, antioxidants, or stabilizers.
- Adjust pH, viscosity, and other parameters to optimize the gel formulation.
Our Gel Development Services
- Formulation Development: Comprehensive studies of desired gel properties, drug compatibility, and selection of appropriate raw materials.
- Preformulation Studies: Evaluation of drug-polymer compatibility, solubility and stability studies.
- Prototyping: Preparation of the initial gel formulation and evaluation of its physical, chemical and biological properties.
- Optimization: Modification of the formulation by adjusting the concentration of polymers, solvents and other excipients to achieve the desired drug release profile and gel properties.
- Scale-up and Manufacturing: Scale-up optimized formulations to larger batches to ensure consistent quality and reproducibility.
Contact us today to learn more about our services and how we can support your pharmaceutical gel development projects.
